Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis

출처 : Nature
등록일 : 2020-12-23
조회 : 69

<p>※&nbsp;<span style="font-size: 14.6667px; text-align: justify;">Nature에서 제공하는 "회로항상성을 위한 성체 별아교세포 해마 시냅스"에 관한 자료입니다.</span></p><div style="text-align: justify; line-height: 1.8;" align="justify"><span style="font-size: 11pt;">In the adult hippocampus, synapses are constantly formed and eliminated. However, the exact function of synapse elimination in the adult brain, and how it is regulated, are largely unknown. Here we show that astrocytic phagocytosis is important for maintaining proper hippocampal synaptic connectivity and plasticity. By using fluorescent phagocytosis reporters, we find that excitatory and inhibitory synapses are eliminated by glial phagocytosis in the CA1 region of the adult mouse hippocampus. Unexpectedly, we found that astrocytes have a major role in the neuronal activity-dependent elimination of excitatory synapses. Furthermore, mice in which astrocytes lack the phagocytic receptor MEGF10 show a reduction in the elimination of excitatory synapses; as a result, excessive but functionally impaired synapses accumulate. Finally, Megf10-knockout mice show defective long-term synaptic plasticity and impaired formation of hippocampal memories. Together, our data provide strong evidence that astrocytes eliminate unnecessary excitatory synaptic connections in the adult hippocampus through MEGF10, and that this astrocytic function is crucial for maintaining circuit connectivity and thereby supporting cognitive function.</span></div><div style="text-align: justify; line-height: 1.8;" align="justify"><span style="font-size: 11pt;"><br></span></div><div style="text-align: justify; line-height: 1.8;" align="justify"><span style="font-size: 14.6667px;">[참고] 전자신문, <a href="https://www.etnews.com/news/article.html?id=20210105000089" target="_blank">"뇌의 기능・기억력 유지 원리는…KAIST, 뇌 기능 '별아교세포'서 답 찾아"</a>, (2021.01.05)</span></div>

URL : https://www.nature.com/articles/s41586-020-03060-3

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